0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

1
Letter to the Editor   |    
Outcome of Asperger’s Syndrome
HARPREET S. DUGGAL, M.B.B.S., D.P.M.; SIDDHARTHA DUTTA, M.D., D.P.M.; VINOD K. SINHA, M.D., D.P.M.
Am J Psychiatry 2002;159:325-a-326. doi:10.1176/appi.ajp.159.2.325-a

To the Editor: The study by Peter Szatmari, M.D., et al. (1) is a laudable endeavor. Although the authors found no data on the outcome of children with Asperger’s syndrome, Asperger, as cited by Wing (2), emphasized the stability of the clinical picture throughout childhood and adolescence and at least into early adult life, with maturation bringing about an increase in skill level. This study thus confirms, in part, the original observation. Still, there is a paucity of information on the outcome of this disorder in late life.

Another aspect relevant to outcome in Asperger’s syndrome is its psychiatric comorbidity. Comorbid disorders are increasingly being recognized in patients with Asperger’s syndrome (3). It would be interesting to know how comorbidity modifies the course and prognosis of Asperger’s syndrome. We have observed patients with Asperger’s syndrome developing bipolar disorder in late adolescence and early adulthood and responding well to treatment with mood stabilizers. There is some literature suggesting an etiological link between the two conditions (4).

As is implicit in the article, the DSM-IV criteria for Asperger’s syndrome require a change. Relaxation of the criterion for qualitative impairment in social interaction vis-à-vis autistic disorder and the inclusion of features common in Asperger’s syndrome, such as pragmatically impaired speech and motor clumsiness, can be envisaged.

Another issue worth highlighting is the stability of neuropsychological deficits in Asperger’s syndrome. While using the Luria Nebraska Neuropsychological Battery, we observed impairment in more than one brain region (5). Hence, comprehensive neuropsychological assessment and its correlation with other outcome measures in Asperger’s syndrome are encouraged.

Szatmari P, Bryson SE, Streiner DL, Wilson F, Archer L, Ryerse C: Two-year outcome of preschool children with autism or Asperger’s syndrome. Am J Psychiatry  2000; 157:1980-1987
[PubMed]
[CrossRef]
 
Wing L: Asperger’s syndrome: a clinical account. Psychol Med  1981; 11:115-129
[PubMed]
[CrossRef]
 
Gillberg C, Billstedt E: Autism and Asperger syndrome: coexistence with other clinical disorders. Acta Psychiatr Scand  2000; 102:321-330
[PubMed]
[CrossRef]
 
DeLong R: Children with autistic spectrum disorder and a family history of affective disorder. Dev Med Child Neurol  1994; 36:674-687
[PubMed]
 
Duggal HS, Dutta S, Sinha VK, Basu S, Pandey S, Nizamie SH, Nizamie A: Neurobiology of Asperger’s syndrome: a case study and overview. Indian J Psychiatry  2001; 43:267-272
[PubMed]
 
+

References

Szatmari P, Bryson SE, Streiner DL, Wilson F, Archer L, Ryerse C: Two-year outcome of preschool children with autism or Asperger’s syndrome. Am J Psychiatry  2000; 157:1980-1987
[PubMed]
[CrossRef]
 
Wing L: Asperger’s syndrome: a clinical account. Psychol Med  1981; 11:115-129
[PubMed]
[CrossRef]
 
Gillberg C, Billstedt E: Autism and Asperger syndrome: coexistence with other clinical disorders. Acta Psychiatr Scand  2000; 102:321-330
[PubMed]
[CrossRef]
 
DeLong R: Children with autistic spectrum disorder and a family history of affective disorder. Dev Med Child Neurol  1994; 36:674-687
[PubMed]
 
Duggal HS, Dutta S, Sinha VK, Basu S, Pandey S, Nizamie SH, Nizamie A: Neurobiology of Asperger’s syndrome: a case study and overview. Indian J Psychiatry  2001; 43:267-272
[PubMed]
 
+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Web of Science® Times Cited: 1

Related Content
Books
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 21.  >
Topic Collections
Psychiatric News
PubMed Articles