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Letter to the Editor   |    
Dr. Di Maggio and Colleagues Reply
CAROLE DI MAGGIO, M.D.; MARIA MARTINEZ, PH.D.; JEAN-FRANÇOIS MÉNARD, PH.D.; MICHEL PETIT, M.D.; FLORENCE THIBAUT, M.D., PH.D.
Am J Psychiatry 2002;159:322-a-322. doi:10.1176/appi.ajp.159.2.322-a
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To the Editor: We calculated mean ages for the cohorts in our study, taking into account their different age structures. For the third cohort (1965–1984), the maximum age of the individuals was 29 (born in 1967 and hospitalized in 1996.)

In order to take this bias into account, we analyzed the data for only the patients with an onset before age 29 in the three cohorts. The cohort effect remained among the three groups, showing an increasingly lower age at onset of first psychotic symptoms from the first cohort (1905–1944) (23 years) to the third cohort (1965–1984) (20 years) and no effect of gender (p<0.00005).

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