Clinical anecdotes salt the pages of The Noonday Demon and vividly document the complex texture of depressive symptoms. These stories provide the hearth from which the author launches expositions into different aspects of his topic: biochemistry, therapies, epidemiology, history, sociology, politics, evolution, suicide, and related sallies ordered by the author’s insatiable curiosity. He makes a full case for the notion that depression is a symptom that gives rise to a complex of other symptoms. Nothing fits neatly into one basket, and, inevitably, where there is no cure there are many treatments. He warns of charlatans, but clinical variations validate the need for therapeutic options, and although he is open to all responsible alternatives, he champions the methods that served him: psychotropics, psychoanalysis, self-study, love, and determination. He is an especially strong advocate of early and long-term use of antidepressants, convinced by his studies that untreated depression promotes treatment-resistant chronicity. Solomon notes, amid concern with the subtleties of etiology, treatment, and prevention, that the incidence of depression among the poor is greater than twice the national average, and it goes mostly untreated.