This book is hefty in both size and substance. The content is divided into 31 compact, discrete chapters, encompassing every facet of the issue, from epidemiology through evolution, neuroanatomy, neurochemistry, and psychoneuroimmunology. The book deals with the effects of female-sex and male-sex steroids on brain and behavior; comorbid disorders and related diagnoses, including bereavement and grief, personality disorders, eating disorders, and alcohol and drug abuse; adolescent, premenstrual, and postpartum mood changes; gender issues in psychopharmacological and psychotherapeutic treatment; and feminist perspectives on the etiology, manifestations, and treatment of mood disorders in women. Myths are countered with empirical evidence: women’s alcohol dependence is not less serious than men’s; mood disorders and substance abuse are distinct and not different manifestations of the same underlying condition. The book is replete with interesting data and theories, such as why women with premenstrual dysphoria and eating disorders crave carbohydrates. The identification of gaps in the literature should be an inspiration for researchers.