We recently reviewed the literature on the effects of antipsychotic treatment on the expression of receptors associated with multiple neurotransmitter systems (1). Three interesting observations emerged from this review: neurotransmitter receptors are not regulated by antipsychotics in the same manner throughout the brain but, rather, are altered in a fashion specific to each brain region and circuit; typical and atypical antipsychotics have differential effects on the expression of a number of neurotransmitter receptors in a given region of the brain, and there is considerable variability in published reports, in part attributable to different study methods, drug doses, administration schedules, and discrepancies in the definitions of the brain regions studied. In the specific case of NR subunits that Drs. Gurling and Chen raise, the literature is contradictory, but most studies suggest that in many regions of the brain these molecules are in fact increased in number by antipsychotic treatment (Ulas, 1993) and not decreased, as suggested by Drs. Gurling and Chen.