I found chapter 1, "Integrative Psychopharmacology: A Practical Approach to Herbs and Nutrients in Psychiatry," by Richard Brown and Patricia Gerbarg, to be the most useful and best written part of the volume. The authors systematically discuss complementary or alternative medical substances used in mood disorders, anxiety, insomnia, migraine, obesity, the endocrine and reproductive system, cognitive enhancement, and athletic enhancement. Their analyses of the efficacy of the substances are level-headed, presenting well-designed studies when they are available. St. John’s wort (Hypericum perforatum) seems demonstrably effective in treatment of mild depression, particularly in seasonal affective disorder. Its side effects seem to be similar to those of SSRIs. S-Adenosylmethionine (SAMe) seems to be convincingly effective in depression with practically no side effects. SAMe is a physiological substance concentrated in the brain and liver, which is involved in three major central pathways (transmethylation, transsulfuration, and transaminopropylation). Brown and Gerbarg discuss its use in detail, including for fibromyalgia, attention deficit hyperactivity disorder, and osteoarthritis. The reader will find discussions on most complementary or alternative medical substances here, including gingko, kava, ginseng, and saw palmetto.