As an orientation to what lies ahead, a brief foreword paints in broad strokes the demographics of nicotine-related morbidity and mortality, discusses some of nicotine’s unique and paradoxical properties relative to other abused psychoactive substances (for example, it blocks as well as stimulates its receptor and increases rather than decreases the number of its receptors when taken exogenously), and presages the sections that follow on the emerging data for a therapeutic use of nicotine. Nontechnical readers will find the foreword a better starting point than chapter 1, "Neurobiology and Clinical Pathophysiology," which, without warmup or access to a definition of terms, introduces the nicotine receptor, "also known as the nicotinic acetylcholine receptor (nAChR)…a ligand-gated ion channel." Nothing else in this informative book matches the density of technical terms and concepts of the first chapter’s opening paragraph. Potential purchasers who might be attending an APA annual meeting and browsing through books at the American Psychiatric Press kiosk between seminars might thumb to chapter 1 for a sense of the book’s content. Many will put Nicotine in Psychiatry back on the shelf, incorrectly assuming that it contains little of relevance to their clinical practice. However, if they deal with patients who struggle with smoking cessation or have Alzheimer’s dementia, schizophrenia, an affective disorder, Parkinson’s, attention deficit hyperactivity disorder, autism, Tourette’s disorder, obesity, or a host of other diagnoses, nothing could be farther from the truth.