We are living in an exciting time. Exciting for us as clinicians and researchers, but most of all for those who are suffering from the disorders that are discussed in these two books. The first edition of Essential Psychopharmacology was so successful that the publishers came back for an update. And an update it is: in addition to the different DSM-IV diagnostic criteria, the latest approved drugs and the related neurotransmitter systems, newer mood stabilizers, cognitive enhancers, sexual arousal mechanisms, hormones, peptides, second messenger systems, and pharmacokinetic principles (e.g., the P450 system) are described as well. Essential Psychopharmacology of Depression and Bipolar Disorder consists of three of the chapters from Essential Psychopharmacology: Neuroscientific Basis and Practical Applications and is for those who want to limit their reading to the mood disorders. There is certainly a gap between what could be done and what happens every day in the clinic. New psychotropic drugs, new mechanisms of actions, and new indications are available to us every day. If all clinicians adhere to the principles laid down in Essential Psychopharmacology: Neuroscientific Basis and Practical Applications, many more patients will be treated effectively.