0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

1
Letter to the Editor   |    
Yohimbine for Anxiety Disorders
STUART WATSON, M.D., M.R.C.PSYCH.; ALLAN H. YOUNG, M.D., PH.D., M.R.C.PSYCH.
Am J Psychiatry 2001;158:1340-1340. doi:10.1176/appi.ajp.158.8.1340

To the Editor: We read the article by Floyd R. Sallee, M.D., Ph.D., et al. (1) with great interest. The authors used the growth hormone response to the α2-adrenergic antagonist yohimbine as a measure of presynaptic norepinephrine activity in a study comparing anxious children with comparison subjects. There are, however, methodological problems inherent in the use of growth hormone as a measure of norepinephrine activity, largely because the release of growth hormone from the pituitary is inhibited by cortisol (2). The authors appeared to measure a single baseline blood sample for each subject for the estimation of cortisol content and reported that there was no significant difference in baseline cortisol levels between comparison children (mean=6.5 g/ml, SD=2.8) and children with anxiety disorders (mean=9.1 g/ml, SD=8.4). Measuring single blood samples of cortisol is often unreliable, and integrated measures of cortisol output are preferred (3). In view of the effect of cortisol on growth hormone release, we believe it would be prudent for these authors to examine a robust measure of cortisol as a covariate of growth hormone response. We further suggest that all studies in which neurotransmitter function is inferred from pituitary hormone measures must measure corticosteroids as a potentially confounding covariate.

Sallee FR, Sethuraman G, Sine L, Liu H: Yohimbine challenge in children with anxiety disorders. Am J Psychiatry 2000; 157:1236-  1242
 
Watson S, Porter RJ, Young AH: Effect of hydrocortisone on the pituitary response to growth hormone releasing hormone. Psychopharmacology 2000, at http://dx.doi.org/10.1007/s002130000491
 
Kirschbaum C, Hellhammer DH: Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology  1994; 19:313-333
[PubMed]
[CrossRef]
 
+

References

Sallee FR, Sethuraman G, Sine L, Liu H: Yohimbine challenge in children with anxiety disorders. Am J Psychiatry 2000; 157:1236-  1242
 
Watson S, Porter RJ, Young AH: Effect of hydrocortisone on the pituitary response to growth hormone releasing hormone. Psychopharmacology 2000, at http://dx.doi.org/10.1007/s002130000491
 
Kirschbaum C, Hellhammer DH: Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology  1994; 19:313-333
[PubMed]
[CrossRef]
 
+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Web of Science® Times Cited: 1

Related Content
Books
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 47.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 47.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 42.  >
Gabbard's Treatments of Psychiatric Disorders, 4th Edition > Chapter 42.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 47.  >
Topic Collections
Psychiatric News
Read more at Psychiatric News >>
PubMed Articles