To the Editor: Dr. Bressan and colleagues present findings that are consistent with our findings of a correlation between D2 receptor occupancy and depression, but their findings resemble ours even more than they suggest. The highest significant correlation with striatal D2 receptor occupancy we found was with the total score on the Montgomery-Åsberg Depression Rating Scale (rs=0.46, N=22, p=0.02) (p. 1020). This resembles the correlation they found between striatal D2 receptor occupancy and BPRS depression item scores (r=0.52, p=0.03) (Bressan et al., 2000). Like Dr. Bressan et al., we also found no correlation between total psychopathology scale scores and striatal D2 receptor occupancy (Pilowsky et al., 1993). Actually, this leads to the main conclusion of their original study: poor clinical response does not appear to be accounted for by differential blockade or inadequate occupancy of striatal D2 receptors by antipsychotic medication (Pilowsky et al., 1993).