The most significant association with D2 occupancy in the study by Lieuwe de Haan, M.D., et al. was negative subjective experience. In our study, high D2 occupancy was associated with mild rather than severe depressive symptoms. Patients frequently complain about taking antipsychotic medications, even in the absence of overt motor side effects. It is possible that this behavior reflects the emergence of the mild depressive symptoms identified in both of these studies. This phenomenon might have important implications for drug choice, dosing, and treatment-adherence strategies. Although our findings are consistent with those of Dr. de Haan et al., both are preliminary, and full elucidation is awaited in larger prospective studies.