The study of Dr. Michelson et al. (1) seems to be a second such study, although most of their patients were almost recovered, as indicated by their Hamilton depression scale scores. Nonetheless, the results of visual analogue scales measuring mood and energy did not indicate their complete recovery. The fact that amantadine added to fluoxetine significantly improved energy levels and approached statistical significance for mood improvement strongly supports the possibility of at least subjectively insufficient recovery of the patients’ depression at baseline. The mean mood changes in the visual analogue scales from baseline (higher values represent greater improvement) were 8.7 (amantadine added), 1.4 (buspirone added), and 0.6 (placebo added); the mean energy changes were 9.5, 2.1, and –3.2, respectively. There was no difference between the addition of buspirone and the addition of placebo in mood or energy change, although the addition of amantadine was significantly better than the addition of placebo, particularly in energy change. Also, there was no difference among the groups in changes measured by the Beck Depression Inventory. These findings suggest that buspirone added to fluoxetine cannot improve subjective mood or energy in mild depression.