Darier’s disease is an autosomal dominant disorder characterized by altered keratinization of the epidermis, nails, and mucous membranes. It was first discovered in an American patient who developed the lesions under a knapsack while training for the U.S. Army in 1862. It usually begins in the first or second decade of life and is found in equivalent numbers among men and women. It is a rare condition, affecting one person in 100,000. Darier’s disease is frequently worse in the summer, when it is exacerbated by heat, humidity, ultraviolet B light, and mechanical trauma. Affective disorders, mainly bipolar disorders, that appeared as a result of Darier’s disease have been reported recently, but they are considered rare complications. The association between the two diseases has been postulated to result from a defect in cell adhesion expressed in both the skin and the brain, which share a common ectodermal origin (1). Treatment is supportive, with removal from and education about sun exposure. Topical retinoids are used to treat the rash; oral retinoids are reserved to treat more severe forms of the disorder.