The editors, Drs. Strain and Stitzer, and their associates at Johns Hopkins in Baltimore are to be commended for the scope and merit of this volume. Despite multiple authorship, the organization and quality of the chapters are uniformly excellent and there is extensive citation of the literature. After a review of the history of methadone maintenance treatment and regulatory/policy issues, chapters 3–5 review in detail the pharmacology, induction/withdrawal, and maintenance dosing in methadone maintenance treatment. Medical and psychiatric comorbidity issues are reviewed, followed by an excellent chapter that emphasizes the importance and benefits of integrating psychosocial treatments, including family therapies, that we currently employ. The chapter on program organization and operations provides useful guidelines for staffing and for dealing with problem behaviors (e.g., the aggressive patient, drug dealing near the clinic, intoxicated patients, etc.). The final chapters present a comprehensive and insightful review of special treatment issues for women and updates the reader on other medications such as levomethadyl acetate, buprenorphine, clonidine, and lofexidine.