To the Editor: It is well recognized that tricyclic antidepressants, particularly in an overdose, may cause a variety of cardiac effects including QT interval prolongation on ECG (1). Newer antidepressants, including trazodone, have been associated with few cardiac side effects. The manufacturer of trazodone has received no reports of QT interval prolongation associated with trazodone at therapeutic doses or in overdose (personal communication, Mark Forest, Pharm.D., Bristol-Myers Squibb, Sept. 17, 1997). Trazodone has very rarely been associated with ventricular tachycardia (2), and there is one case report of QT prolongation and polymorphous ventricular tachycardia associated with trazodone in combination with the antiarrhythmic amiodarone (3). I report here the case of a patient who experienced significant QT prolongation after a trazodone overdose without arrhythmia or other adverse consequences.