While there is mounting evidence from different research teams working at different sites with different populations (1–5) that devout religious beliefs and practices in older adults are associated with lower rates of depression, Dr. Miller and colleagues’ report is the first with children and one of the first concerning middle-aged adults. The rising epidemic of depression in children speaks to the importance and urgency of identifying sociocultural factors responsible for or protective of this trend. The Miller et al. study is also important because it included a large proportion of Catholics (70%), whereas our studies have involved primarily Protestants (more than 80%). Further epidemiologic studies are clearly needed in children, adolescents, young adults, and persons from non-Christian religious backgrounds (e.g., Jews, Moslems, Hindus) to determine to what extent these results can be generalized more broadly.