To the Editor: Eric R. Kandel, M.D., valiantly tries to show the molecular basis of psychopathology and psychotherapy, but I fear that the chasm between brain and mind remains unbridged. Suggesting a molecular basis for the way in which experience changes the brain provides a mechanism for the way in which experience and brain interact but leaves unanswered how one becomes the other and what part this plays in psychopathology and psychotherapy. We already know that brain and mind interact. And we know, for some disorders, that some of the variance of etiologies comes from biological factors and that drugs can effect marked changes in some symptoms. I do not see what Dr. Kandel’s "new intellectual framework" adds.