The book is divided into three sections—Diagnostic Considerations, Biology, and Treatment. All chapters are well worth reading, but if I had to select a favorite from each section, here are my choices. "Genetics," by Simpson and DePaulo, is an outstanding summary of the search for the genetic underpinnings of bipolar disorder complete with explanations of methodology, problems faced by genetic researchers, and the state of research well into 1996. Section 2 contains the obligatory chapters on serotonin, catecholamines, acetylcholine, and γ-aminobutyric acid. It also has a tired chapter on electrophysiology that concludes with the following statement: "It is difficult not to be disappointed by the relatively small yield of results after more than 50 years of EEG research and 25 years of ERP investigation" (p. 185). It also has a superb contribution, "Brain Imaging," by George, Ketter, Kimbrell, and Post. After a lucid general description of the newer brain imaging technologies, these authors expound on difficulties encountered in studying mania and present the state of the science in this area.