We agree that although the distinction is often not made clinically, it is important to differentiate alcohol withdrawal delirium from other symptoms in delirium tremens, since autonomic hyperactivity does not follow the same time course as does the delirium. As regards the choice of a benzodiazepine for treatment of alcohol withdrawal, we believe that lorazepam or oxazepam, which have an intermediate duration of action, is preferable to longer-acting benzodiazepines for two reasons. First, they do not require hydroxylation, so that in the context of hepatic dysfunction, they will not accumulate to toxic levels. Second, and more important, since treatment of alcohol withdrawal is increasingly being done in an ambulatory setting, the use of a long-acting benzodiazepine may be problematic: it has a greater risk for additive sedation if alcohol is consumed concurrently. Finally, the clinical experience of Dr. Adinoff notwithstanding, it is not clear that in all cases, the aggressive treatment of early alcohol withdrawal can prevent the development of delirium tremens. The fact that delirium tremens can have its onset in the absence of early withdrawal symptoms argues against a simple progressive model for all cases of alcohol withdrawal. Clarification of these important clinical issues will also depend upon systematic empirical investigation.