The Textbook of Psychopharmacology continues to have four major sections: Principles of Psychopharmacology; Classes of Psychiatric Treatments; Animal and Human Pharmacology, Clinical Psychobiology, and Psychiatric Syndromes; and Psychopharmacological Treatment. The authors of the individual chapters were carefully selected to provide the most comprehensive and up-to-date versions of their topics. The second edition also seems to be better illustrated than the first edition, particularly in the Principles of Psychopharmacology section, which has been expanded from six to nine chapters. There are new chapters on animal models of Alzheimer’s disease and neuroendocrine and immune system pathology in psychiatric disease. The second section has two additional chapters, one on venlafaxine and one on ECT. The latter chapter includes some information on rapid-rate transcranial magnetic stimulation, an evolving experimental treatment for depression. The third section has an additional chapter on biology of personality disorders. The final section has an additional chapter on treatment of insomnia. Each chapter is well referenced, and the referencing includes citations through 1997. The treatment chapters follow a similar format and include general principles of treatment and approaches to treatment resistance. The index is quite useful.