Schizophrenia is a severe mental illness that profoundly affects an individual’s functioning in numerous domains, including interpersonal (i.e., social skills), intrapersonal (i.e., sense of self), occupational, and cognitive (e.g., conceptual skills). Since the advent of neuroleptics in the 1950s, major inroads have been made in ameliorating deficits in these areas. However, traditional neuroleptics, such as chlorpromazine, while alleviating many florid "positive symptoms" of schizophrenia (i.e., hallucinations and delusions), did not "restore" or "remediate" social or occupational skills. Furthermore, many neuroleptics were beset by untoward side effects (e.g., akathisia), and they were fairly ineffective in reducing the "negative symptoms" of the disorder (e.g., flat affect, anhedonia), which are often associated with negative outcome. Thus, from the 1970s to the present, many psychosocial and pharmacological interventions emerged to address treatment gaps in the literature. From the pioneering work on token economies to family treatment of expressed emotion, the unfolded picture was one of multimodal intervention. Thus, this book is written within the spirit of psychosocial and pharmacological integrated therapies.