Dr. Trimble's review of neurological syndromes associated with the limbic and related systems serves as the context in which to consider the major psychiatric diagnostic categories. For each major disorder, he provides a qualitative review of the relevant literature, which usually incorporates previously described investigative techniques. The two chapters on epilepsy and the dementias carefully delineate the overlap among these "classic" neurological disorders and the major psychiatric conditions. In this context, similarities in genetic studies (e.g., greater risk of schizophrenia, bipolar disorder, and Alzheimer's disease in monozygotic twins), relevant neurotransmitter systems (e.g., dopamine in Parkinson's disease, Huntington's disease, and schizophrenia), and pharmacotherapeutics (e.g., anticonvulsants in epilepsy and bipolar disorder) are considered. Further, the author also provides data to support the localization of certain psychopathology (e.g., left-sided temporal lobe lesions are more closely associated with schizophrenia-like psychosis; right-sided abnormalities may be more closely linked to affective disorders).