A framework for the book is the biopsychosocial model, popularized by Engel, and most of the authors appear to accept the model, if only tacitly in some instances. The model itself is not critiqued, but perhaps it should be—not to discredit it but somehow to get beyond the lip service we usually pay to it. There can be little disagreement with the concept behind the model; namely, that most clinical phenomena in psychiatry (if not in all of medicine) represent complex, interlocking patterns of biological, psychological, and social processes. The model by itself does not stimulate much controversy. In my experience, however, interesting differences of opinion emerge when timing and sequencing of interactions in the three domains are addressed. I believe that medical students should be aware of these issues because they come up every day in the office, on rounds, and in treatment planning.