It was surprising that despite the international and collaborative nature of the study, the 174 sites that took part were not cited in the article. They were from Europe and North America and recruited both in- and outpatients, but further details were not given. Information on the characteristics of these centers would have been of value in interpreting the data presented, since there was great variability in the number of patients who entered the trial at each center (from one patient in 13 sites to 73 patients at one center). Differences among the centers (e.g., urban versus rural, in- versus outpatient services) might have been a valid reason for such variability, but different enrollment criteria might also have been responsible. This possibility is further supported by the fact that a quite heterogeneous population was recruited. While the majority of the patients had schizophrenia of the paranoid subtype, no information is provided on the number of schizophrenic patients included or their distribution between the two treatment arms, nor is there information on the distribution of chronic patients. In addition, it would have been of interest to know the proportion who were enrolled during an exacerbation of their illness. Around 77% of the group were intolerant of current antipsychotic therapy (excluding haloperidol), but no details on how this intolerance was measured are provided. Finally, patients were required to have a minimum Brief Psychiatric Rating Scale (BPRS) score of 18, but no reason is provided to justify this choice. Overall, it is not clear to which patients the results of the present trial apply.