TO THE EDITOR: I appreciated reading the article by Judith G. Rabkin, Ph.D., M.P.H., and colleagues (1). Their finding, that HIV-infected men were not more depressed as their illness progressed, is consistent with research on the relationship between negative life events and depression. As Kendler and colleagues have shown (2), the relationship is complex and modulated by genetic predisposition. To that equation, Klerman would add such variables as early life experiences, personality traits, coping styles, and social supports (3). Rabkin et al.'s cohort was predominantly white, well educated, generally middle class, and part of a supportive community. Thus, these subjects were probably less likely to be predisposed to depression.