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The American Journal of Psychiatry, VOL. 154, No. 5

REGULAR ARTICLES | May 01, 1997

Effects of the cholecystokinin agonist pentagastrin in patients with generalized anxiety disorder

Am J Psychiatry 1997;154:700-702.

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Abstract

OBJECTIVE: The anxiogenic and panicogenic effects of peripheral administration of the cholecystokinin-B receptor agonist pentagastrin and placebo were evaluated in patients with generalized anxiety disorder and normal comparison subjects. METHODS: Seven patients with generalized anxiety disorder and seven age- and sex-matched normal subjects received an intravenous bolus of placebo and pentagastrin. RESULTS: Panic attacks occurred in five patients with generalized anxiety disorder (71%) and in one normal subject (14%). Patients with generalized anxiety disorder were more likely to report more nonpanic anxiety than were normal subjects. CONCLUSIONS: Patients with generalized anxiety disorder appear to exhibit greater subjective sensitivity to pentagastrin than do normal subjects.

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Effects of the cholecystokinin agonist pentagastrin in patients with generalized anxiety disorder. American Journal of Psychiatry. 1997 May;154(5):700-702.

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