OBJECTIVE: The authors' goal was to determine whether higher doses of
haloperidol improve antipsychotic response. METHOD: During a 2-week,
double-blind, randomized fixed-dose study, 24 psychotic patients were given
4, 10, or 40 mg/day of haloperidol. RESULTS: No clinically relevant
difference between groups in favor of the higher antipsychotic doses could
be detected. CONCLUSIONS: Doses of 4 mg/day of haloperidol appear to be as
effective as higher doses in the treatment of psychosis.