Nine depressed subjects and nine comparison subjects completed a study
of abnormalities in adrenal androgen and cortisol metabolism. Serum levels
of cortisol and dehydroepiandrosterone (DHA) at 8:00 a.m. and 4:00 p.m.
revealed hypercortisolemia and loss of diurnal DHA variation but not
cortisol variation in the depressed group. These findings suggest that in
depression, adrenal androgens, in contrast to cortisol, are partially
regulated by mechanisms independent of ACTH.