The authors measured CSF concentrations of corticotropin-releasing
hormone (CRH) and arginine vasopressin in nine depressed patients before
and after fluoxetine treatment. They found significant decreases in CSF
CRH, CSF arginine vasopressin, and Hamilton depression ratings. Thus, the
therapeutic effect of this serotonin-uptake inhibitor may be related to
diminution of these arousal-promoting neuropeptides.