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Limited therapeutic effect of addition of buspirone in fluvoxamine- refractory obsessive-compulsive disorder

Published Online:https://doi.org/10.1176/ajp.150.4.647

The authors found that buspirone added to the treatment of 33 patients with obsessive-compulsive disorder who were refractory to the serotonin reuptake inhibitor fluvoxamine was no better than placebo in reducing obsessive-compulsive, depressive, or anxiety symptoms. This finding suggests that addition of buspirone to ongoing fluvoxamine therapy is not an effective treatment strategy for most patients with obsessive- compulsive disorder.

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