In an open, nonblind study, 10 patients with Tourette's disorder who
were being treated with haloperidol were videotaped before, while, and
after chewing nicotine gum. The frequency of tics was reduced significantly
during the 30-minute gum-chewing period and during the 1 hour after gum
chewing. Nicotine appears to potentiate haloperidol effects in patients
with Tourette's disorder.