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Value of the DST for predicting response of patients with major depression to hospitalization and desipramine
Am J Psychiatry 1990;147:1488-1492.
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The authors examined the value of the dexamethasone suppression test (DST) for predicting response of patients with unipolar, nonpsychotic major depression to 1 week of hospitalization without antidepressant drugs and to a 4-week trial of desipramine at a fixed plasma level. The rates of response to hospitalization without drug treatment (defined as a score of 12 or less on the Hamilton Rating Scale for Depression) were not significantly different for the patients with a positive DST and those with a negative DST. This finding differs from those of prior studies of the DST and response to placebo. The responses of the DST- positive and DST-negative patients to desipramine also did not differ, a finding that replicates those in some prior reports.

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