The authors determined serotonin2 (5-HT2) binding in the frontal cortex
of 32 suicide victims and 37 subjects who died from nonpsychiatric causes.
The maximum number of binding sites (Bmax) and the affinity (Kd) were
significantly higher in subjects who had committed suicide than in control
subjects. However, there was no difference in Kd between these two groups
after the influence of age, race, sex, and postmortem delay was covaried.
The Bmax of subjects who had committed violent suicide was significantly
greater than that of control subjects.