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Exacerbation of schizophrenia associated with amantadine

Published Online:https://doi.org/10.1176/ajp.143.9.1170

Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication. Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.

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