0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

REGULAR ARTICLES   |    
Intensive treatment with haloperidol of treatment-resistant chronic schizophrenic patients
Am J Psychiatry 1982;139:1466-1468.
text A A A
PDF of the full text article.
Abstract

The authors treated 11 treatment-resistant schizophrenic patients with steadily increasing doses of haloperidol to determine the therapeutic range of plasma concentrations in such patients. Six patients responded, usually within a few weeks of treatment and at doses of 50 mg/day or less; plasma concentrations ranged between 17 and 42 ng/ml. Five patients were unresponsive, despite treatment for 13-22 weeks, doses of haloperidol of 180-270 mg/day, and plasma concentrations of 51- 225 ng/ml. Doses greater than 150 mg/day appear unnecessary, because lesser doses generally provide plasma concentrations of 20-50 ng/ml. Failure to respond within 2 months of reaching such doses or plasma concentrations augurs for continued lack of response.

Abstract Teaser
Figures in this Article

Topics

schizophrenia
Your Session has timed out. Please sign back in to continue.
Sign In Your Session has timed out. Please sign back in to continue.
Sign In to Access Full Content
 
Username
Password
Sign in via Athens (What is this?)
Athens is a service for single sign-on which enables access to all of an institution's subscriptions on- or off-site.
Not a subscriber?

Subscribe Now/Learn More

PsychiatryOnline subscription options offer access to the DSM-5 library, books, journals, CME, and patient resources. This all-in-one virtual library provides psychiatrists and mental health professionals with key resources for diagnosis, treatment, research, and professional development.

Need more help? PsychiatryOnline Customer Service may be reached by emailing PsychiatryOnline@psych.org or by calling 800-368-5777 (in the U.S.) or 703-907-7322 (outside the U.S.).

+

References

+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Web of Science® Times Cited: 41

Related Content
Articles
Books
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 1.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 2.  >
Manual of Clinical Psychopharmacology, 7th Edition > Chapter 9.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 6.  >
The American Psychiatric Publishing Textbook of Psychiatry, 5th Edition > Chapter 10.  >
Topic Collections
Psychiatric News
Read more at Psychiatric News >>
APA Guidelines
PubMed Articles