The authors studied the excretion of 3-methoxy-4-hydroxyphenlyglycol
(MHPG) in 15 hyperactive boys and 13 controls. They further examined soft
neurologic signs and clinical drug response to d-amphetamine administration
for two weeks in the hyperactive boys. MHPG excretion was significantly
lower in the hyperactive boys than in the controls. d- Amphetamine
decreased MHPG excretion significantly in the drug responders only.
Pretreatment MHPG excretion did not predict clinical drug response. The
responders had more soft neurologic signs than the nonresponders.
Furthermore, soft neurologic signs were not related to pretreatment MHPG