Twenty patients were treated with penfluridol and 21 with fluphenazine
for a period of up to 1 year. Penfluridol, an oral neuroleptic administered
weekly was as efficacious as fluphenazine administered twice daily and
appeared to be superior to fluphenazine in improving emotional withdrawal
and anergia. The low incidence of side effects and other signs of toxicity,
coupled with an effective prophylactic activity, suggests that penfluridol
is an important addition to our therapeutic armamentarium for the treatment
of chronic schizophrenia.