The hope presented in this book is that an integration of imaging research with genetic research might move us toward an answer. This book is a fine expression of the momentum spearheaded by the National Institute of Mental Health toward a “circuits” approach to psychiatric disorder and in that sense is a good introduction for anyone interested in psychiatric research of areas in favor by those authorities doing much of the funding today. In this reviewer’s early training, disorders that could be located anatomically to a circuit were considered to be “neurological” and therefore unlikely to be treatable; disorders of biochemistry and receptors were thought to be somehow functional and more amenable to orally administered pharmacological interventions that by their nature affected whole metabolic systems in the brain. Clearly that mode of thinking is no longer with us. Specific circuits might be dysfunctional in specific psychiatric disorders, and those circuitry abnormalities might be revealed by the new imaging techniques. Different but specific genotypes could cause the same circuitry abnormality, for instance, by revving up the output of an inhibitory circuit or alternatively increasing its input. Thus, we may have some answers if we study the gene and the imaging together, even if the genes or the imaging alone do not seem to give us diagnostic tools. The book is strong on models, but as we learned from psychoanalysis, a smoothly worded model does not guarantee veracity. This book’s hope is well formulated in the forward by Fred Goodwin. Steve Strakowski’s honest summary in the final chapter makes it clear that the book’s usefulness is for the psychiatric researcher and not the practitioner or diagnostician.