The authors describe three postmenopausal women with agitated psychotic
depression, increased water ingestion, and electrolyte values consistent
with the syndrome of inappropriate antidiuretic hormone (ADH) secretion.
They hypothesize that this clinical triad represents a syndrome reflecting
underlying dysfunction of the hypothalamus and limbic system of the brain.
The diagnosis of inappropriate ADH in one of the patients was directly
confirmed by a recently developed serum radioimmunoassay.