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Articles   |    
Doxepin: Is a Single Daily Dose Enough?
Am J Psychiatry 1974;131:1027-1029.
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Director, West-Ros-Park Mental Health Center, Boston State Hospital and Associate Clinical Professor of Psychiatry, Boston University School of Medicine

Investigator, Psychopharmacology Research Group, Boston State Hospital and Clinical Instructor of Psychiatry, Tufts University School of Medicine

Research Consultant, Boston State Hospital and Psychiatrist to the McLean Hospital, Belmont, Mass., and Professor of Psychiatry, Tufts University School of Medicine

1974, The American Psychiatric Association

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The authors conducted a post hoc comparison of two very similar doxepin studies that included outpatients with mixed anxiety and depression. The first study used a three-times-a-day schedule, and the second used a bedtime schedule. All differences between the two treatments favored the bedtime regimen. Although the reports cannot take the place of a direct comparison between the two dosage schedules, they offer evidence for the usefulness and value of single-dose bedtime medication for anxious-depressed outpatients receiving doxepin treatment.

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