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Drugs and Group Psychotherapy in Neurotic Depression
LINO COVI; RONALD S. LIPMAN; LEONARD R. DEROGATES; JAMES E. SMITH, III; JOSEPH H. PATTISON
Am J Psychiatry 1974;131:191-198.
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Associate Professor of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Md. 21205 and Director, Outpatient Department, Gundry Hospital, Baltimore

Chief, Clinical Studies Section, Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Md.

Assistant Professor of Medical Psychology, Johns Hopkins School of Medicine, Baltimore, Md. 21205

Instructor in Psychiatry, Johns Hopkins School of Medicine, Baltimore, Md. 21205

Assistant Professor of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Md. 21205

1974, The American Psychiatric Association

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Abstract

Chronically depressed neurotic women outpatients were randomly assigned, after a two-week placebo washout period, to receive one of three medications (imipramine, diazepam, or placebo) and to either weekly group psychotherapy or biweekly brief supportive sessions at one of two clinics. Analyses of covariance for the first 16 weeks of active treatment (N = 146) indicated a marked therapeutic advantage for imipramine on most of the outcome measures. No advantage for group therapy was detected on these measures. Patients who showed improvement were continued in further controlled drug treatment for up to a total of 71 weeks; preliminary analyses of this phase showed some continuing advantage for treatment with imipramine.

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