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The American Journal of Psychiatry, VOL. 130, No. 7

Articles | July 01, 1973

Fluphenazine Enanthate and Fluphenazine Decanoate: A Comparison of Their Duration of Action and Motor Side Effects

H. M. VAN PRAAG; L. C. W. DOLS

Am J Psychiatry 1973;130:801-804.

Professor of Biological Psychiatry, Department of Biological Psychiatry, Psychiatric University Clinic, 59 Oostersingel, Groningen, the Netherlands

Research Assistant, Department of Biological Psychiatry, Psychiatric University Clinic, 59 Oostersingel, Groningen, the Netherlands

1973, The American Psychiatric Association

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Abstract

Fluphenazine enanthate and fluphenazine decanoate—two long-acting neuroleptics—were administered in a controlled comparative study to 30 patients with acute psychoses of different character and origin. The study compared the duration of action and affinity for the extrapyramidal system of the two drugs. The decanoate ester acted longer than the enanthate ester and provoked fewer motor side effects. Since these side effects greatly reduce the patient's motivation to cooperate in taking depot medication, the decanoate ester is to be preferred.

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