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Levoamphetamine and Dextroamphetamine: Differential Effect on Aggression and Hyperkinesis in Children and Dogs
L. EUGENE ARNOLD; VLADIMIR KIRILCUK; SAMUEL A. CORSON; ELIZABETH O'L. CORSON
Am J Psychiatry 1973;130:165-170.
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Assistant Professor of Psychiatry and Pediatrics, Ohio State University, Columbus, Ohio 43210

Research Associate in Psychiatry, Ohio State University, Columbus, Ohio 43210

Professor of Psychiatry (Physiology) and Biophysics, Ohio State University, Columbus, Ohio 43210

1973, The American Psychiatric Association

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Abstract

In laboratory experiments with hyperkinetic, untrainable dogs and in a comparison of levoamphetamine, dextroamphetamine, and placebo in children, levoamphetamine and dextroamphetamine were found to be approximately equal in calming an aggressive, hostile dog and in benefiting "unsocialized-aggressive" children: dextroamphetamine was more effective than levoamphetamine in calming "nervousness" and hyperactivity in dogs and in overanxious-hyperkinetic children. These data suggest that in the hyperkinetic syndrome, aggression and hostility may be benefited equally by levoamphetamine or dextroamphetamine via a dopaminergic mechanism, while anxiety and overactivity may be benefited significantly only by the dextro isomer via a norepinephrinergic mechanism.

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Animal model for study of hyperkinesis and aggression. Psychopharmacol Bull 1978;14(1):68.
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