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Biochemical and Pharmacological Variations in Manic-Depressive Illness
CHRISTIAAN D. VAN DER VELDE; MALCOLM W. GORDON
Am J Psychiatry 1972;129:337-342.
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Research Psychiatrist, Abraham Ribicoff Research Center, Norwich Hospital, Norwich, Conn. 06360

Director of the Abraham Ribicoff Research Center, Abraham Ribicoff Research Center, Norwich Hospital, Norwich, Conn. 06360

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Abstract

The response of 21 manic-depressives to imipramine was followed over a period of two years, during which both manic and depressed states were treated. Most patients responded differently to this treatment at different times. The variation in response is considered in the context of a hypothecated biochemical instability in the manic-depressive that is manifest in behavioral, pharmacological, and biochemical measures.

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