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Amphetamine Withdrawal: Affective State, Sleep Patterns, and MHPG Excretion
Am J Psychiatry 1972;129:263-269.
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Department of Psychology, University of Chicago, Chicago, Ill.

Associate Professor of Psychiatry, Tufts University, Medford, Mass., and Director, Sleep and Dream Laboratory, Boston State Hospital, Boston, Mass.

Director, Neuropsychopharmacology Laboratory, and Associate Professor of Psychiatry, Massachusetts Mental Health Center, Harvard Medical School, 74 Fenwood Rd., Boston, Mass. 02115

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The authors found that the clinical depressions which occurred following withdrawal from amphetamines after prolonged abuse were temporally associated with a decrease in the excretion of 3-methoxy-4-hydroxyphenylglycol (MHPG), a metabolite of norepinephrine, and altered EEG sleep patterns including an increased amount of D sleep (REM sleep). As the depressions subsided, MHPG excretion increased and measures of D sleep decreased.

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