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The American Journal of Psychiatry, VOL. 128, No. 11

Articles | May 01, 1972

Safety of High-Dose Tricyclic Antidepressant Therapy

MARC A. SCHUCKIT; JOHN P. FEIGHNER

Am J Psychiatry 1972;128:1456-1459.

Chief Resident, Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla, Calif. 92037

Assistant Clinical Professor, Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla, Calif. 92037

1972, American Psychiatric Association

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Abstract

The authors report on a series of depressed inpatients and outpatients who received greater-than-recommended doses of the tricyclic antidepressants for 1,505 patient days. These patients tolerated the drugs with a minimum of side effects and, when tested, showed no evidence of hematologic, hepatic, or ocular damage. The authors give some possible explanations for the individual variations in tolerance and response to this high-dose regimen.

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