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Leukocytosis During Lithium Treatment
DENNIS L. MURPHY; FREDERICK K. GOODWIN; WILLIAM E. BUNNEY, JR.
Am J Psychiatry 1971;127:1559-1561.
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Chief of Clinical Research Units, Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md.

Chief, Section on Psychiatry, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md.

1971, American Psychiatric Association

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Abstract

An increase in circulating leukocytes accompanied lithium treatment in 28 consecutively studied manic-depressive patients. Acutely manic patients showed the most marked changes and maintained leukocyte counts of 10,000 to 14,000 during the first two to four weeks of lithium administration. Leukocyte counts returned to pre-lithium levels within one week after discontinuation of the drug. In 11 patients receiving lithium for longer periods the elevation in white cell count persisted throughout treatment.

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