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The American Journal of Psychiatry, VOL. 127, No. 9

Articles | March 01, 1971

Tranylcypromine-Trifluoperazine Combination in the Treatment of Schizophrenia

DAVID L. HEDBERG; JOHN H. HOUCK; BERNARD C. GLUECK, JR.

Am J Psychiatry 1971;127:1141-1146.

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Research Psychiatrist, Institute of Living, 200 Retreat Ave., Hartford, Conn. 06103

Medical Director, Institute of Living, 200 Retreat Ave., Hartford, Conn. 06103

Director of Research, Institute of Living, 200 Retreat Ave., Hartford, Conn. 06103

1971, American Psychiatric Association

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Abstract

Ninety-six schizophrenic patients participated in a double-blind, crossover study of the efficacy of trifluoperazine and tranylcypromine therapy alone and in combination. Pseudoneurotic patients had a statistically significant response to tranylcypromine; paranoid (chronic undifferentiated) patients responded best to the combination therapy. The authors urge the use of computer-derived profiles of patients' symptom clusters rather than their diagnoses to ensure selection of the optimum drug therapy.

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