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The American Journal of Psychiatry, VOL. 121, No. 5

Articles | November 01, 1964

COMBINED PERPHENAZINE-AMITRIPTYLINE AS ADJUVANT THERAPY IN PSYCHIATRIC AFTERCARE

ELSE B. KRIS; DAVID GERST

Am J Psychiatry 1964;121:498-501.

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Director of Psychiatric Research (Social Psychiatry), State of New York

Psychiatrist, Research Division, Dept. of Mental Hygiene, Lower Manhattan After-Care Clinic, New York, N. Y.

1960 by The American Psychiatric Association

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Abstract

An amitriptyline-perphenazine combination was used to treat the mixed anxiety, tension, and depression which may occur in patients being maintained on phenothiazines. Of 33 such patients seen regularly in a community aftercare clinic, 29 (88%) showed considerable or total remission of symptoms. Dizziness, nausea, and vomiting required discontinuing amitriptyline-perphenazine therapy in 3 patients. One patient complained of dry mouth. This drug combination may be of great help in the maintenance therapy of psychotic outpatients. Further study would seem to be warranted.

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