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CLINICAL NOTES   |    
COMBINED PSYCHOPHARMACEUTICAL TREATMENT IN 460 NEUROPSYCHIATRIC PATIENTS
VERONICA M. PENNINGTON
Am J Psychiatry 1962;118:935-937.
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Chief, Hospital Section of Psychiatry, VA Center, Jackson, Miss.

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Abstract

The combination of meprobamate, chlorpromazine, and nialamide appeared to effect the best results. Sixty-one percent of the group on these medicaments were greatly improved. Meprobamate, chlorpromazine, and tofrānil produced the next greatest improvement in 59%; meprobamate and chlorpromazine in 58%.Side effects showed a decreased percentage in multiple medication. This can be partially accounted for by the fact that in the single medication group larger doses were required. The ameliorating effect of meprobamate on side reactions was also considered to be a factor in reducing the side effects by decreasing anxiety, bettering sleep and thereby reducing the amount of phenothiazines necessary for improvement.

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